The risks associated with use of flumazenil, a benzodiazepine antagonist, outweigh any potential benefits for most patients.
Acute management consists of maintaining airway, respiration, and haemodynamic support while excluding other diagnoses. The effects of benzodiazepines may be potentiated if taken in combination with other central nervous system (CNS) depressants, such as alcohol and opioids. Larger doses can cause coma, respiratory depression, and, without appropriate treatment, even death, particularly in the context of mixed ingestion with other CNS depressants. The key feature of overdose is excessive sedation. Benzodiazepine overdose can be intentional (e.g., as an act of self-harm), as part of recreational misuse, or accidental (e.g., medication error).īenzodiazepines are the most commonly prescribed medications for anxiety, sedation, and sleep.
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